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Related Concept Videos

Vitamins01:30

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Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
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Role of Skin in Vitamin D Synthesis01:23

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
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Role of Vitamins in Maintaining Bone Health01:25

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Renal Failure: Dose Adjustments01:11

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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
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Connective Tissue Cell Types01:22

Connective Tissue Cell Types

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Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
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Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Hypervitaminosis D without toxicity.

Jasmin Rahesh1, Victoria Chu1, Alan N Peiris1,2

  • 1School of Medicine, Texas Tech University Health Sciences CenterLubbockTexas.

Proceedings (Baylor University. Medical Center)
|February 18, 2020
PubMed
Summary
This summary is machine-generated.

High vitamin D levels (hypervitaminosis D) can occur without toxicity, often due to supplement misuse. This case highlights the need for better regulation of over-the-counter vitamin D products to prevent potential harm.

Keywords:
1,25(OH)2D25(OH)Dhypervitaminosis Dover-the-counter supplementsvitamin D toxicity

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Area of Science:

  • Endocrinology
  • Clinical Medicine
  • Nutritional Science

Background:

  • Vitamin D deficiency is a widespread health concern.
  • Vitamin D toxicity is increasingly reported, primarily linked to improper use of supplements.
  • Maintaining adequate vitamin D levels is crucial for bone health and other physiological functions.

Observation:

  • A patient presented with markedly elevated 25-hydroxyvitamin D (25(OH)D) levels (196 ng/mL).
  • Despite high vitamin D levels, the patient showed no clinical signs or biochemical evidence of toxicity.
  • Serum calcium, phosphorus, and 1,25-dihydroxyvitamin D levels remained within the normal range.

Findings:

  • The patient's hypervitaminosis D was attributed to the misuse of OTC vitamin D supplements.
  • Cessation of supplements led to the normalization of 25(OH)D and urine calcium levels.
  • This suggests a potential for significant vitamin D accumulation without immediate adverse effects.

Implications:

  • OTC vitamin D supplements may pose a risk of incidental toxicity due to lack of regulation.
  • The Food and Drug Administration (FDA) should consider enhanced oversight of OTC supplements.
  • Further research is needed to understand the threshold for vitamin D toxicity and safe supplementation practices.