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Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
Published on: September 30, 2021
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Acquired hemophilia A.
Yadav Pandey1, Dinesh Atwal2, Manojna Konda1
1Department of Internal Medicine, University of Arkansas for Medical SciencesLittle RockArkansas.
Proceedings (Baylor University. Medical Center)
|February 18, 2020
Summary
Acquired hemophilia A, an autoimmune disorder, requires prompt diagnosis and treatment. Early use of factor bypassing agents and immunosuppression significantly improves patient outcomes, offering a lifesaving intervention for this rare bleeding condition.
Area of Science:
- Hematology
- Immunology
- Internal Medicine
Background:
- Acquired inhibitors of coagulation are rare, life-threatening autoimmune disorders.
- Autoantibody against factor VIII defines acquired hemophilia A, the most common inhibitor type.
Purpose of the Study:
- To present a clinical series of acquired hemophilia A patients.
- To evaluate treatment outcomes and highlight diagnostic indicators.
Main Methods:
- Retrospective analysis of nine acquired hemophilia A patients.
- Treatment strategies included factor bypassing agents (e.g., recombinant factor VIIa) for bleeding and immunosuppression (steroids, rituximab, cyclophosphamide) for autoantibody elimination.
Main Results:
- Seven of nine patients (77%) achieved a good clinical outcome.
- Bleeding diathesis and prolonged aPTT were common presenting features.
- Factor bypassing agents and immunosuppressive therapies were key to management.
Conclusions:
- Acquired hemophilia A must be suspected in patients with unexplained bleeding and prolonged aPTT.
- Early intervention with factor bypassing agents and immunosuppression is crucial for survival and good outcomes.
Keywords:
Acquired hemophilia Aacquired inhibitors of coagulationactivated prothrombin complex concentratesrecombinant factor VIIaMore Related Videos
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