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Mephedrone and Alcohol Interactions in Humans.
Esther Papaseit1,2, Clara Pérez-Mañá1,2, Elizabeth B de Sousa Fernandes Perna3
1Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol (IGTP), Badalona, Spain.
Frontiers in Pharmacology
|February 18, 2020
Summary
Combining mephedrone (4-MMC) with alcohol intensifies cardiovascular effects and euphoria, while reducing alcohol
Area of Science:
- Pharmacology
- Neuroscience
- Toxicology
Background:
- Mephedrone (4-MMC) is a synthetic cathinone and new psychoactive substance.
- Co-use with alcohol (ethanol) is common.
- Interactions between mephedrone and alcohol require investigation.
Purpose of the Study:
- To evaluate the subjective, cardiovascular, hormonal, and pharmacokinetic interactions between mephedrone and alcohol in humans.
- To compare the effects of combined use versus individual drug use.
Main Methods:
- Double-blind, randomized, cross-over, placebo-controlled clinical trial.
- Eleven male volunteers received oral doses of mephedrone, alcohol, their combination, or placebo.
- Assessed physiological, psychomotor, subjective, and pharmacokinetic parameters.
Main Results:
- The combination of mephedrone and alcohol amplified cardiovascular effects and euphoria compared to individual substances.
- Mephedrone attenuated the sedative effects of alcohol.
- The abuse liability of the combination was higher than mephedrone alone.
Conclusions:
- Mephedrone and alcohol co-administration leads to enhanced subjective and cardiovascular effects.
- This combination presents a greater abuse potential than mephedrone alone.
- Findings align with interactions observed between alcohol and other psychostimulants.
Keywords:
4-methylmethcathinone (mephedrone)alcohol (ethanol)interactionnew psychoactive substancepharmacokineticspharmacologic effectsMore Related Videos
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