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Association between interleukin gene polymorphisms and multiple myeloma susceptibility

Muhamaad Naveed Shahzad1, Iqra Ijaz2, Syed Shah Zaman Haider Naqvi3

  • 1Stem Cell Laboratory, Department of Hematology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

Molecular and Clinical Oncology
|February 18, 2020
PubMed

Insights

Interleukin gene polymorphisms, particularly IL-1 and IL-6, are linked to an increased risk of multiple myeloma (MM). Specific genetic variations may serve as important markers for MM risk assessment and potential therapeutic strategies.

Area of Science:

  • Genetics
  • Oncology
  • Immunology

Background:

  • Multiple myeloma (MM) is a hematological malignancy with complex genetic underpinnings.
  • Interleukin (IL) genes play crucial roles in immune regulation and inflammation, potentially influencing cancer development.
  • Understanding the association between IL gene polymorphisms and MM risk is vital for risk stratification and targeted therapies.

Purpose of the Study:

  • To investigate the relationship between interleukin family gene polymorphisms and the risk of developing multiple myeloma (MM).
  • To identify specific IL gene variants associated with increased MM susceptibility.
  • To explore the potential of these polymorphisms as biomarkers for MM prognosis.

Main Methods:

  • A retrospective observational study was conducted, analyzing data from sixteen case-control studies.
  • The study included 2,597 patients diagnosed with MM and 3,851 healthy controls.
  • Meta-analysis was employed to assess the association between various IL gene polymorphisms (IL-1, IL-6, IL-10) and MM risk.

Main Results:

  • Specific genotypes of IL-6 and IL-1 GG were found to increase MM risk (OR=1.14 and OR=1.16, respectively).
  • A significant association was observed between IL-6 and IL-10 T:C polymorphisms and MM risk (ORs ranging from 1.26 to 1.37).
  • Polymorphisms in IL-1β1464G>C, IL-6572G>C, IL-1α-889C>T, and IL-1β-3737C>T showed significant associations with increased MM risk (P<0.05 and P<0.001).

Conclusions:

  • Certain interleukin gene polymorphisms, including IL-1, IL-6, and IL-10, are significantly associated with an increased risk of multiple myeloma.
  • Specific single nucleotide polymorphism (SNP) loci identified may serve as valuable genetic markers for MM screening.
  • These findings suggest potential therapeutic strategies and prognostic indicators for patients with multiple myeloma based on genetic profiling.
Keywords:
interleukin family gene polymorphismsmultiple myelomaprognosissystematic review

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