Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

1.9K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.9K
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors01:19

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors

472
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
472

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lineage-specific chromatin poising enforced by ETS-IRF composite elements determines the divergent interferon responses of plasmacytoid dendritic cells and epithelial cells.

bioRxiv : the preprint server for biology·2026
Same author

Beyond the Bilayer: Organization and Interactions in the <i>Arabidopsis thaliana</i> Cell Wall-Plasma Membrane System in Atomistic Simulations.

The journal of physical chemistry. B·2026
Same author

PFDA Influences the Structure of the Globular Milk Protein, α-Lactalbumin: Implications for Its Ability to Bind a Physiologically Crucial Cofactor.

Chemical research in toxicology·2026
Same author

Swiss community-based surveillance of respiratory virus co-occurrence in 2022-2024.

Microbiology spectrum·2026
Same author

Protein-Linker Co-engineering for Broad-Spectrum Antiviral Development against Enveloped Viruses.

ACS materials letters·2026
Same author

Direct Measurement of Protein Pair Interaction Potential.

ACS nano·2026
Same journal

Taphonomic analysis at Liang Bua reveals the behavioral and technological capabilities of <i>Homo floresiensis</i>.

Science advances·2026
Same journal

Targeting granule initiation and amyloplast structure to create giant starch granules in wheat.

Science advances·2026
Same journal

A meta-analysis of carbon losses and gains from tropical moist forest degradation and regeneration.

Science advances·2026
Same journal

Ancient DNA reveals elite dynastic rule among Iron Age Eurasian Steppe nomads.

Science advances·2026
Same journal

Targeting astrocytic Dp71 attenuates BBB disruption after traumatic brain injury through WTAP-associated m<sup>6</sup>A regulation of MMP2.

Science advances·2026
Same journal

Pancreatic α cells are required for nutrient homeostasis by regulating dynamic β cell networks in islets.

Science advances·2026
See all related articles

Related Experiment Video

Updated: Dec 28, 2025

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
11:34

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Published on: May 5, 2014

14.2K

Modified cyclodextrins as broad-spectrum antivirals.

Samuel T Jones1,2, Valeria Cagno1,3, Matej Janeček1

  • 1Institute of Materials, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland.

Science Advances
|February 18, 2020
PubMed
Summary
This summary is machine-generated.

New nontoxic cyclodextrin-based macromolecules show broad-spectrum virucidal activity against viruses like herpes simplex virus (HSV) and respiratory syncytial virus (RSV). These promising antivirals are biocompatible and resist viral mutation.

More Related Videos

Engineering Antiviral Agents via Surface Plasmon Resonance
13:00

Engineering Antiviral Agents via Surface Plasmon Resonance

Published on: June 14, 2022

2.6K
Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
09:29

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

30.7K

Related Experiment Videos

Last Updated: Dec 28, 2025

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
11:34

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Published on: May 5, 2014

14.2K
Engineering Antiviral Agents via Surface Plasmon Resonance
13:00

Engineering Antiviral Agents via Surface Plasmon Resonance

Published on: June 14, 2022

2.6K
Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
09:29

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

30.7K

Area of Science:

  • Virology and Nanotechnology
  • Drug Discovery and Development

Background:

  • Viral infections pose a significant global health threat, necessitating the development of novel antiviral therapies.
  • Ideal antiviral drugs should be nontoxic and possess irreversible virucidal activity, but existing virucidal agents are often cytotoxic.
  • Previous research introduced nontoxic, broad-spectrum virucidal gold nanoparticles, highlighting the potential of nanotechnology in antiviral development.

Purpose of the Study:

  • To develop novel, nontoxic, broad-spectrum virucidal agents based on modified cyclodextrins.
  • To mimic heparan sulfate structures using cyclodextrins modified with mercaptoundecane sulfonic acids for enhanced antiviral action.
  • To evaluate the efficacy and safety of these novel macromolecules against a range of viral pathogens.

Main Methods:

  • Synthesis of cyclodextrins modified with mercaptoundecane sulfonic acids to create heparan sulfate mimetics.
  • In vitro assessment of virucidal activity against multiple viruses, including herpes simplex virus (HSV), respiratory syncytial virus (RSV), dengue virus, and Zika virus.
  • Ex vivo testing in respiratory and vaginal tissue culture models, and in vivo efficacy studies in mice challenged with HSV-2.

Main Results:

  • The modified cyclodextrins demonstrated broad-spectrum, nontoxic virucidal activity at micromolar concentrations in vitro.
  • Effective ex vivo antiviral activity was observed against laboratory and clinical strains of RSV and HSV-2 in relevant tissue models.
  • In vivo administration in mice before HSV-2 inoculation proved effective, and the compounds passed a mutation resistance test, unlike acyclovir.

Conclusions:

  • Cyclodextrin-based macromolecules modified with mercaptoundecane sulfonic acids represent a promising new class of broad-spectrum, nontoxic virucidal agents.
  • These novel compounds show potential for preventing and treating viral infections, including those caused by HSV and RSV.
  • The observed resistance to viral mutation suggests a significant advantage over existing antiviral therapies.