Pregnancy in sickle cell trait: what we do and don't know

Area of Science:

• Genetics and Hematology
• Reproductive Health
• Nephrology

Background:

• Sickle cell trait (SCT) is a genetic carrier state for sickle cell disease, caused by the HBB rs334 mutation.
• SCT is linked to increased risks of venous thromboembolism and chronic kidney disease.
• The impact of pregnancy on SCT-related health risks is largely unknown.

Purpose of the Study:

• To investigate the effects of pregnancy on SCT-related health risks.
• To explore adverse pregnancy outcomes associated with SCT.
• To highlight the need for further research due to SCT's high prevalence.

Main Methods:

• This study is a review of existing literature.
• Analysis of epidemiological data on SCT and pregnancy outcomes.
• Identification of maternal complications and their association with SCT.

Main Results:

• SCT is associated with an elevated risk of venous thromboembolism, including pulmonary embolism.
• SCT may increase the risk of chronic kidney disease.
• Pregnancy outcomes in SCT carriers require further investigation due to potential links with bacteriuria, pre-eclampsia, and prematurity.

Conclusions:

• While SCT does not affect life expectancy, it poses risks for thromboembolism and kidney disease.
• The specific risks and outcomes of pregnancy in individuals with SCT remain unclear.
• Further research is crucial to understand and manage pregnancy in SCT carriers given its global prevalence.