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Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

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Published on: February 23, 2017

Substituted hydroxyapatite coatings of bone implants.

Daniel Arcos¹, María Vallet-Regí¹

¹Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital 12 de Octubre i + 12, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain. arcosd@ucm.es vallet@ucm.es and CIBER de Bioingeniería Biomateriales y Nanomedicina (CIBER-BBN), Spain.

Journal of Materials Chemistry. B

|February 18, 2020

Summary

Substituted hydroxyapatite (HAp) coatings enhance orthopedic and dental implant healing. These advanced coatings offer antibiotic and osteoinductive properties, expanding applications in bone regeneration therapies and clinical prospects.

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Area of Science:

Biomaterials Science
Orthopedic Engineering
Dental Implantology

Background:

Surface modification of implants accelerates bone healing.
Hydroxyapatite (HAp) coatings are widely used due to biocompatibility and osteoconductivity.
Ionic substitutions in HAp offer enhanced properties like antibiotic and osteoinductive effects.

Purpose of the Study:

To review and critically analyze advances in substituted hydroxyapatite coatings.
To explore the expanded applications of these coatings in bone regeneration.
To discuss in vivo outcomes and clinical prospects.

Main Methods:

Review of recent literature on substituted hydroxyapatite coatings.
Analysis of deposition techniques for orthopedic and dental implants and scaffolds.
Evaluation of protein and growth factor immobilization capabilities.

Main Results:

Substituted HAp coatings show promise for orthopedic and dental implants and macroporous scaffolds.
Hybrid coatings incorporating proteins and growth factors enhance bone healing.
Ionic substitutions provide added therapeutic value beyond basic biocompatibility.

Conclusions:

Substituted hydroxyapatite coatings represent a significant advancement in implant technology.
Their versatility extends to bone regeneration therapies and the development of functional hybrid coatings.
Clinical translation of these advanced coatings is promising for improved patient outcomes.