Related Experiment Video

Updated: Dec 28, 2025

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
09:02

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions

Published on: September 22, 2023

2.0K

Coronaviruses: a paradigm of new emerging zoonotic diseases

Cristiano Salata1, Arianna Calistri1, Cristina Parolin1

  • 1Department of Molecular Medicine, University of Padova, Via Gabelli 63, 35121, Padova, Italy.

Pathogens and Disease
|February 18, 2020
PubMed

Insights

A novel coronavirus (2019-nCoV) emerged in Wuhan, China, causing a rapid global outbreak. Molecular analysis indicates a bat origin, underscoring the zoonotic threat of coronaviruses.

Area of Science:

  • Virology
  • Epidemiology
  • Zoonotic Diseases

Background:

  • A novel coronavirus, identified as 2019-nCoV, emerged in Wuhan, China.
  • The outbreak rapidly escalated, with over 31,000 confirmed cases and 638 deaths within one month.

Purpose of the Study:

  • To report the emergence and initial spread of a novel human coronavirus.
  • To investigate the potential origin and zoonotic capacity of 2019-nCoV.

Main Methods:

  • Epidemiological surveillance of reported cases.
  • Molecular analysis to determine viral origins.

Main Results:

  • The virus spread rapidly internationally from Wuhan.
  • Initial molecular data suggested a bat origin with potential intermediate hosts.

Conclusions:

  • The emergence of 2019-nCoV highlights the significant zoonotic potential of coronaviruses.
  • Rapid global spread necessitates urgent public health interventions and further research.

Keywords:
2019-nCoVMERSSARScoronaviruszoonosis

More Related Videos

Protocols for Investigating the Host-tissue Distribution, Transmission-mode, and Effect on the Host Fitness of a Densovirus in the Cotton Bollworm11:12

Protocols for Investigating the Host-tissue Distribution, Transmission-mode, and Effect on the Host Fitness of a Densovirus in the Cotton Bollworm

Published on: April 12, 2017

8.9K
Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting08:40

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

Published on: March 1, 2019

59.6K

Related Concept Videos

Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
24.8K
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
618
Principles of Disease Surveillance01:26

Principles of Disease Surveillance

Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
411
Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
39.4K
Retroviruses02:33

Retroviruses

Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
14.5K
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
49.0K