Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Analgesia and Pain Management

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

Peripheral Artery Disease V: Postoperative Nursing Management

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Peptic Ulcer Disease IV: Management

Peptic Ulcer Disease IV: Management

Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...

Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Milk-alkali syndrome due to regular consumption of thermal water.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2025

Same author

Sulfur oxidation and reduction are coupled to nitrogen fixation in the roots of the salt marsh foundation plant Spartina alterniflora.

Nature communications·2024

Same author

Investigation of the physico-chemical properties of Ni-Mg-Al-La catalysts from ultrasound-assisted synthesis.

Ultrasonics sonochemistry·2024

Same author

A diagnostic support system based on pain drawings: binary and k-disease classification of EDS, GBS, FSHD, PROMM, and a control group with Pain2D.

Orphanet journal of rare diseases·2023

Same author

[Rare diseases in the differential diagnosis of myalgia].

Der Nervenarzt·2022

Same author

[Rare diseases in the differential diagnosis of myalgia].

Schmerz (Berlin, Germany)·2022

Search research articles

Related Experiment Video

Updated: Dec 28, 2025

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

[Pain management in osteoporosis].

L Heuchemer¹, D Emmert¹, T Bender¹

¹Zentrum für Seltene Erkrankungen (ZSEB), Universitätsklinikum Bonn, Venusberg-Campus 1, 53127, Bonn, Deutschland.

Schmerz (Berlin, Germany)

|February 18, 2020

Summary

Osteoporosis, a common bone density disease, increases fracture risk and causes pain, impacting quality of life. Effective pain management involves understanding its mechanisms, risk factors, and treatment options.

Keywords:

Absorptiometry, dual-energy x‑ray Analgesics, opioid Bisphosphonates Fracture risk Physical therapy modalities

More Related Videos

Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention

Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention

Published on: April 26, 2024

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

Published on: November 8, 2024

Related Experiment Videos

Last Updated: Dec 28, 2025

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention

Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention

Published on: April 26, 2024

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

Published on: November 8, 2024

Area of Science:

Orthopedics
Rheumatology
Pain Medicine

Background:

Osteoporosis is a global health issue characterized by reduced bone density.
This condition elevates fracture risk and can lead to decreased height.
Osteoporosis is frequently linked to acute and chronic pain, particularly back pain, significantly impairing patient quality of life.

Purpose of the Study:

To provide a comprehensive review of pain management strategies in osteoporosis.
To elucidate the underlying pathomechanisms contributing to pain in osteoporosis.
To detail risk factors and diagnostic procedures for osteoporosis.

Main Methods:

Literature review of pharmacological treatments for osteoporosis pain.
Analysis of nonpharmacological interventions for osteoporosis-related pain.
Examination of pathomechanisms, risk factors, and diagnostic methods for osteoporosis.

Main Results:

Identification of various pharmacological agents for pain relief in osteoporosis.
Evaluation of nonpharmacological approaches, including physical therapy and lifestyle modifications.
Detailed explanation of the pathophysiology, epidemiological factors, and diagnostic criteria.

Conclusions:

Effective pain management in osteoporosis requires a multifaceted approach.
Understanding disease mechanisms and risk factors is crucial for tailored treatment.
Comprehensive management strategies improve patient outcomes and quality of life.