Related Experiment Video

Updated: Dec 28, 2025

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.7K

Mortality After Paclitaxel-Coated Device Use in Patients With Chronic Limb-Threatening Ischemia: A Systematic Review

Krystal Dinh1, Miguel Lemos Gomes2, Shannon D Thomas2,3,4

  • 1Department of Vascular Surgery, Westmead Hospital, Sydney, NSW, Australia.

Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists
|February 19, 2020
PubMed

Insights

Paclitaxel-coated devices showed no significant difference in all-cause mortality compared to uncoated devices for patients with chronic limb-threatening ischemia (CLTI). This meta-analysis of randomized controlled trials suggests similar short- to midterm survival outcomes.

Area of Science:

  • Vascular Medicine and Interventional Cardiology
  • Biomaterials and Medical Devices

Background:

  • Chronic limb-threatening ischemia (CLTI) is a severe condition associated with high mortality and morbidity.
  • Paclitaxel-coated devices are utilized in peripheral artery disease (PAD) to improve outcomes, but their impact on mortality in CLTI patients requires evaluation.

Purpose of the Study:

  • To determine the risk of all-cause mortality in patients with CLTI treated with paclitaxel-coated devices versus uncoated controls.

Main Methods:

  • A systematic literature search of multiple databases (PubMed, Embase, Cochrane, etc.) was conducted up to November 5, 2019.
  • Included were randomized controlled trials (RCTs) comparing paclitaxel-coated devices to uncoated devices in PAD patients with at least 6-month follow-up, focusing on CLTI or CLTI subgroups.
  • All-cause mortality was the primary endpoint, analyzed using a random effects model, with results expressed as relative risk ratios (RR) and 95% confidence intervals (CI).

Main Results:

  • Eleven RCTs comprising 1450 patients (866 paclitaxel-coated, 584 uncoated) were analyzed; 94.3% of patients had CLTI.
  • The mean follow-up duration was 25.6 months.
  • There was no statistically significant difference in all-cause mortality between the paclitaxel-coated device group (18.6% deaths) and the uncoated control group (19.9% deaths), with an RR of 0.93 (95% CI 0.78 to 1.12, p=0.45).

Conclusions:

  • The study found no significant difference in short- to midterm all-cause mortality for CLTI patients treated with paclitaxel-coated devices compared to uncoated controls.
  • These findings suggest comparable survival rates between the two treatment strategies in this high-risk patient population.
Abstract

Keywords:
Balloon angioplastychronic limb-threatening ischemiacritical limb ischemiadrug-coated balloondrug-eluting balloondrug-eluting stentdrug-releasing balloonpaclitaxelpaclitaxel-coated balloonpercutaneous transluminal angioplastyperipheral artery disease

More Related Videos

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity09:38

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity

Published on: January 31, 2025

796
Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging10:50

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging

Published on: June 29, 2013

12.7K

Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
187
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
285
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
253
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
275
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
243
Pulmonary Embolism III: Nursing Management01:27

Pulmonary Embolism III: Nursing Management

A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
257