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The effects of a multispecies synbiotic on microbiome-related side effects of long-term proton pump inhibitor use: A

Angela Horvath1,2, Bettina Leber3, Nicole Feldbacher4,5

  • 1Division of Gastroenterology and Hepatology, Medical University of Graz, Graz, Austria. angela.horvath@medunigraz.at.

Scientific Reports
|February 19, 2020
PubMed

Insights

A three-month synbiotic intervention improved gut barrier function and quality of life in patients on long-term proton pump inhibitor (PPI) therapy, suggesting a way to reduce PPI-related side effects.

Area of Science:

  • Gastroenterology
  • Microbiome Research
  • Pharmacology

Background:

  • Long-term proton pump inhibitor (PPI) use is associated with changes in the intestinal microbiome.
  • These microbiome alterations may contribute to PPI-related side effects.
  • The gut microbiome's role in mitigating PPI side effects warrants investigation.

Purpose of the Study:

  • To evaluate the impact of a three-month multispecies synbiotic intervention.
  • To assess effects on intestinal inflammation, gut barrier function, and microbiome composition.
  • To examine changes in laboratory parameters and quality of life in long-term PPI users.

Main Methods:

  • A study involving 36 patients on long-term PPI therapy.
  • A daily multispecies synbiotic was administered for three months.
  • Clinical observation continued for an additional three months post-intervention.

Main Results:

  • Significant reduction in elevated zonulin levels, indicating improved gut barrier function.
  • Alterations in microbiome composition, with decreased Stomatobaculum and increased Bacillus.
  • Significant improvements in gastrointestinal quality of life and certain laboratory parameters (albumin, alkaline phosphatase, thrombocyte count, aspartate transaminase).

Conclusions:

  • Synbiotic intervention can substantially reduce microbiome-related side effects of long-term PPI use.
  • The study highlights the potential of synbiotics in managing PPI-associated gastrointestinal issues.
  • Further research is needed to optimize synbiotic dosage and duration for maximum efficacy.

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