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Related Concept Videos

piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
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pre-mRNA Processing02:01

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In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a “cap” to the 5’ end of the growing transcript. In this process, a 5’ phosphate is replaced by modified guanosine that has a methyl group attached to it (7-Methyl...
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Ribosomal RNA Synthesis02:53

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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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A Rapid High-throughput Method for Mapping Ribonucleoproteins RNPs on Human pre-mRNA
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Author Correction: Ribosomes guide pachytene piRNA formation on long intergenic piRNA precursors.

Yu H Sun1, Jiang Zhu1, Li Huitong Xie1

  • 1Center for RNA Biology: From Genome to Therapeutics, Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA.

Nature Cell Biology
|February 19, 2020
PubMed
Summary

This study has a published amendment. Please refer to the link at the top of the paper for the updated information and revised findings.

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Area of Science:

  • This research falls within the scope of scientific publishing and academic communication.

Background:

  • An amendment has been issued for this scientific paper.
  • This amendment is accessible through a direct link provided at the beginning of the document.

Purpose of the Study:

  • To notify readers about a published amendment to the original paper.
  • To ensure readers access the most current and accurate version of the research.

Main Methods:

  • The primary method involves providing a notification about the amendment.
  • Readers are directed to a link for accessing the updated paper.

Main Results:

  • An amendment to the paper is now available.
  • The amendment can be accessed via a link at the top of the paper.

Conclusions:

  • Readers should consult the amended version for the latest information.
  • Accessing the linked amendment ensures engagement with the most up-to-date research findings.