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Updated: Dec 28, 2025
Isolating Nasal Olfactory Stem Cells from Rodents or Humans
Published on: August 22, 2011
Single-cell analysis of olfactory neurogenesis and differentiation in adult humans
Michael A Durante1,2,3,4, Stefan Kurtenbach2,3, Zoukaa B Sargi4,5
1Medical Scientist Training Program, University of Miami Miller School of Medicine, Miami, FL, USA.
Abstract:
The presence of active neurogenic niches in adult humans is controversial. We focused attention to the human olfactory neuroepithelium, an extracranial site supplying input to the olfactory bulbs of the brain. Using single-cell RNA sequencing analyzing 28,726 cells, we identified neural stem cell and neural progenitor cell pools and neurons. Additionally, we detailed the expression of 140 olfactory receptors. These data from the olfactory neuroepithelium niche provide evidence that neuron production may continue for decades in humans.
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