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Fatal encephalitis associated with coronavirus OC43 in an immunocompromised child

Anna Nilsson1, Niklas Edner2, Jan Albert3,4

  • 1Department of Women's and Children's Health, Childhood Cancer Research Unit, Astrid Lindgren Children's Hospital, Karolinska Institutet, Stockholm, Sweden.

Infectious Diseases (London, England)
|February 19, 2020
PubMed

Insights

A child undergoing chemotherapy for acute lymphoblastic leukemia (ALL) developed fatal brain inflammation (encephalitis). Human coronavirus OC43 (HCoV-OC43) was detected in the brain, despite negative spinal fluid tests.

Area of Science:

  • Pediatric Oncology
  • Infectious Diseases
  • Neurology

Background:

  • Acute lymphoblastic leukemia (ALL) is a common childhood cancer.
  • Chemotherapy for ALL can lead to immunosuppression, increasing infection risk.
  • Viral encephalitis is a serious complication in immunocompromised patients.

Keywords:
Coronavirusbrain biopsyencephalitisnext generation sequencing

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