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Author Spotlight: Advancing Coral Culture - Creating a Semi-Quantitatively Controlled Microenvironment System to Counter Current Limitations
Published on: July 21, 2023
Sinulasterols A-C, three new bioactive oxygenated steroids from the South China Sea soft coral Sinularia depressa
Min Yang1, Wan-Xiang Cui2, Heng Li3
1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555, Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China.
Abstract:
Three new oxygenated steroids, sinulasterols A-C (1-3), along with seven known related steroids 4-10, were isolated from the Chinese soft coral Sinularia depressa. The structures of the new compounds were established from extensive spectroscopic data analyses and by comparison of their spectral data with those reported in the literature. Among the new compounds, metabolites 1 and 2 featured on unusual C-18 oxygenated pattern. In the TNF-α bioassay, compound 4 exhibited a potent inhibitory activity (IC50 = 12.1 μM), which was analogous to the positive control dexamethasone (IC50 = 8.7 μM), metabolites 1 and 2 displayed a moderate inhibitory activity (IC50 51.1 μM and 22.7 μM respectively).
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