Related Experiment Video
Updated: Dec 28, 2025
10:19
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
19.7K
Does ketamine ameliorate the social stress-related bladder dysfunction in mice?
Stephen Shei-Dei Yang1,2, Hsi-Hsien Chang1, Shang-Jen Chang1,2
1Division of Urology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan.
Neurourology and Urodynamics
|February 19, 2020
Summary
Ketamine may improve social stress-induced infrequent voiding and reduce elevated BDNF levels in mice. However, it did not reverse detrusor overactivity or impaired contractility, indicating limited effects on overall bladder dysfunction.
Area of Science:
- Neuroscience
- Urology
- Pharmacology
Background:
- Social stress (SS) is linked to bladder dysfunction.
- Brain-derived neurotrophic factor (BDNF) may play a role in stress-related conditions.
- Investigating therapeutic interventions for stress-induced urological issues is crucial.
Purpose of the Study:
- To determine if ketamine can alleviate bladder dysfunction caused by social stress in mice.
- To assess the impact of ketamine on social stress-induced changes in voiding frequency and serum BDNF levels.
- To evaluate ketamine's effect on detrusor overactivity and contractility.
Main Methods:
- FVB mice were exposed to social stress (SS) or control conditions for 4 weeks.
- Ketamine (25 mg/kg/day) was administered to stressed mice at different time points.
- In vivo cystometry, tissue bath wire myography, and ELISA for BDNF were performed.
Main Results:
- Social stress led to infrequent voiding, elevated serum BDNF, detrusor overactivity, and impaired contractility.
- Ketamine administration reversed the trend of decreased voiding frequency in stressed mice.
- Ketamine reduced elevated serum BDNF levels but did not improve detrusor overactivity or contractility.
Conclusions:
- Short-term ketamine administration may improve social stress-related infrequent voiding and elevated serum BDNF.
- Ketamine did not reverse the urodynamic and myographic impairments associated with social stress.
- Further research is needed to understand ketamine's complex effects on stress-induced bladder dysfunction.
