Related Experiment Video
Updated: Jun 16, 2026
10:26
RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
28.0K
Low Epstein-Barr virus count in sinonasal inverted papilloma
Alexandra Schindele1, Anna Holm1, Karin Nylander2
1Department of Clinical Sciences, Otorhinolaryngology - Östersund, Umeå University, Umeå, Sweden.
Acta Oto-Laryngologica
|February 19, 2020
Summary
Epstein-Barr virus (EBV) was detected in 30% of sinonasal inverted papilloma (SIP) cases, but at low levels. This suggests EBV is unlikely to be a primary cause of SIP or its malignant transformation.
Area of Science:
- Otolaryngology
- Oncology
- Virology
Background:
- Sinonasal inverted papilloma (SIP) is a benign sinonasal tumor with high recurrence and malignant transformation rates.
- Epstein-Barr virus (EBV) is an oncogenic herpesvirus with variable reported associations with SIP.
- Current understanding of EBV's role in SIP pathogenesis is limited.
Purpose of the Study:
- To investigate the presence and quantify Epstein-Barr virus (EBV) in sinonasal inverted papilloma (SIP) tissue.
- To determine the distribution of EBV within the epithelial and connective tissue compartments of SIP.
- To clarify the association between EBV and SIP, including its potential role in malignant transformation.
Main Methods:
- Analysis of 53 SIP patient biopsies from the University Hospital of Umeå.
- Utilized Epstein-Barr Encoded Region (EBER) in situ hybridization for viral detection.
- Quantified EBER-positive cells in both epithelial and connective tissue.
Main Results:
- Epstein-Barr virus (EBV) was detected in 30% of sinonasal inverted papilloma (SIP) cases.
- A subset (19%) exhibited an abundance of EBV-stained cells, while the remainder showed low counts.
- Viral distribution analysis mapped EBV presence within SIP tissues.
Conclusions:
- The study found a low prevalence and count of Epstein-Barr virus (EBV) in sinonasal inverted papilloma (SIP).
- These findings indicate that EBV is unlikely to be a significant causative agent in SIP development.
- The low EBV association suggests it plays a minimal role in the malignant transformation of SIP.
Related Concept Videos
01:28Herpes
Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
01:17Poliomyelitis
Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...