Related Experiment Video
Updated: Dec 28, 2025
A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
Published on: June 4, 2021
Multiphase MR Angiography Collateral Map: Functional Outcome after Acute Anterior Circulation Ischemic Stroke
Hyun Jeong Kim1, Sang Bong Lee1, Jin Woo Choi1
1From the Department of Radiology (H.J.K.), Neurology (S.B.L., T.J.L., Y.J.J., S.Y.R.), and Neurosurgery (H.J.L.), Daejeon St. Mary's Hospital, The Catholic University of Korea, Daejeon, Korea; Departments of Radiology (J.W.C., H.G.R.), Neurosurgery (Y.S.J., Y.I.C.), and Neurology (J.J.P.), Konkuk University Medical Center, Konkuk University School of Medicine, 120-1 Neungdong-Ro, Gwangjin-Gu, Seoul 05030, Korea; Department of Radiology, Gachon University Gil Medical Center, Incheon, Korea (E.Y.K.); Siemens Healthineers Ltd, Seoul, Korea (I.S.K.); and Clinical Research Center, Asan Institute for Life Science, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea (J.S.L.).
A novel MR angiography collateral map accurately estimates collateral circulation in acute ischemic stroke, aiding treatment decisions. Better collateral grades correlate with improved functional outcomes, highlighting its clinical reliability.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Collateral circulation is crucial for determining tissue fate and treatment outcomes in acute ischemic stroke.
- Accurate collateral assessment is essential for optimal treatment decisions in acute ischemic stroke.
- Dynamic contrast-enhanced MR angiography offers a potential tool for evaluating collateral status.
Purpose of the Study:
- To validate the utility of multiphase collateral imaging data sets (MR angiography collateral map) from dynamic contrast-enhanced MR angiography.
- To assess the predictive value of these maps for functional outcomes in acute ischemic stroke patients.
- To establish the reliability of MR angiography collateral maps for clinical use.
Main Methods:
- Secondary analysis of a prospective observational study involving patients with acute ischemic stroke.
- Inclusion criteria: occlusion/stenosis of internal carotid artery or MCA M1 segment, evaluated within 8 hours of symptom onset.
- Collateral grading using a six-scale MR acute ischemic stroke collateral (MAC) score derived from MR angiography collateral maps.
- Multivariable logistic regression analysis to identify predictors of favorable functional outcomes.
Main Results:
- One hundred fifty-four participants were analyzed (mean age 69 years, 99 men).
- Independent predictors of favorable functional outcomes included younger age, lower NIHSS score, higher MAC scores (3-5), and successful early reperfusion.
- A significant negative linear association was observed between collateral perfusion grades and functional outcomes (P < .001).
Conclusions:
- The MR angiography collateral map is a clinically reliable tool for estimating collateral status in acute ischemic stroke.
- This imaging technique provides valuable, patient-specific information regarding ischemic progression.
- The findings support the integration of MR angiography collateral maps into clinical practice for acute ischemic stroke management.
