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Related Experiment Video

Updated: Dec 28, 2025

Murine Fecal Isolation and Microbiota Transplantation

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

Gut microbiome and cardiovascular disease.

Yongzhong Zhao¹, Zeneng Wang

¹Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

Current Opinion in Cardiology

|February 19, 2020

Summary

The gut microbiome influences cardiovascular disease (CVD) through inflammation and metabolites. Understanding these gut-heart connections is crucial for developing new CVD treatments and improving heart health.

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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

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Last Updated: Dec 28, 2025

Murine Fecal Isolation and Microbiota Transplantation

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Area of Science:

Microbiology
Cardiology
Metabolomics

Background:

Gut microbiome's role in cardiovascular health and disease is increasingly recognized.
Research focuses on gut dysbiosis, CVD risk factors, and microbial metabolites.
Gut microbiome is a critical factor in cardiovascular research.

Purpose of the Study:

To highlight the association between gut microbiome and cardiovascular disease (CVD).
To emphasize the molecular mechanisms linking gut microbiome to CVD.
To categorize microbial metabolites' effects on cardiovascular health.

Main Methods:

Review of current literature on gut microbiome and CVD.
Discussion of molecular mechanisms, including microbial translocation and metabolite-induced inflammation.
Summarization of findings on microbiome modulation of drug efficacy and exercise effects.

Main Results:

Gut microbes can translocate to the aorta, initiating inflammation due to gut barrier defects.
Microbial-derived metabolites can induce inflammation and renal insufficiency.
Beneficial and deleterious metabolites impacting cardiovascular health are identified.

Conclusions:

Gut microbiome plays a significant role in cardiovascular disease pathogenesis.
Microbial metabolites and translocation are key mechanisms linking gut health to heart disease.
Modulating the gut microbiome holds potential for CVD treatment and prevention.