Related Experiment Video
Updated: Dec 28, 2025
08:41
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
8.7K
Sinus Floor Augmentation Using Recombinant Human Bone Morphogenetic Protein-2 With Hydroxyapatite: Volume Assessment.
Jung Woo Nam1, Young Deok Chee1, Young Bum Park2
1Department of Oral & Maxillofacial Surgery and Dental Research Institute, Wonkwang University College of Dentistry, Gunpo.
The Journal of Craniofacial Surgery
|February 19, 2020
Summary
Bone morphogenetic protein-2 with hydroxyapatite granules (BMP-2/hydroxyapatite) demonstrated superior maxillary sinus floor augmentation compared to conventional bone grafts. This bone graft material offers predictably reliable outcomes for volumetric changes and material density.
Area of Science:
- Biomaterials Science
- Oral and Maxillofacial Surgery
- Regenerative Medicine
Background:
- Maxillary sinus floor augmentation is crucial for dental implant placement.
- Evaluating novel bone graft materials is essential for improving surgical outcomes.
- Bone morphogenetic protein-2 with hydroxyapatite granules (BMP-2/hydroxyapatite) is a potential alternative to conventional grafting materials.
Purpose of the Study:
- To compare the efficacy of BMP-2/hydroxyapatite with conventional bone graft materials for maxillary sinus floor augmentation.
- To assess volumetric and height changes of grafted materials.
- To evaluate the reliability of BMP-2/hydroxyapatite in achieving predictable augmentation outcomes.
Main Methods:
- A comparative study involving patients undergoing maxillary sinus floor augmentation.
- Two groups were formed: one receiving BMP-2/hydroxyapatite and the other conventional bone graft materials.
- Computed tomography (CT) scans were utilized for pre-operative, post-operative, and 6-month follow-up assessments.
- Three-dimensional reconstruction software was employed to measure volumetric and height changes of the grafted materials.
Main Results:
- The BMP-2/hydroxyapatite group exhibited significantly greater mean volumetric increases (0.25 cc) compared to the conventional materials group (-0.07 cc).
- Mean height changes favored the BMP-2/hydroxyapatite group (0.34 mm) over the conventional group (-0.63 mm).
- Higher rates of volumetric and height changes were observed in the BMP-2/hydroxyapatite group, indicating effective augmentation.
Conclusions:
- BMP-2/hydroxyapatite demonstrates superior performance in maxillary sinus floor augmentation compared to conventional bone graft materials.
- This biomaterial offers improved volumetric changes and grafted material densities.
- BMP-2/hydroxyapatite provides predictably reliable outcomes for sinus lift procedures.
