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iDISK: the integrated DIetary Supplements Knowledge base.

Rubina F Rizvi1,2, Jake Vasilakes1,2, Terrence J Adam1,2

  • 1Institute for Health Informatics, University of Minnesota, Minneapolis, Minnesota, USA.

Journal of the American Medical Informatics Association : JAMIA
|February 19, 2020
PubMed
Summary
This summary is machine-generated.

A new integrated DIetary Supplement Knowledge base (iDISK) standardizes information from four resources. This publicly available knowledge base improves dietary supplement (DS) knowledge dissemination.

Keywords:
RxNormdietary supplementsknowledge representationterminologyunified medical language system

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Area of Science:

  • Biomedical Informatics
  • Pharmacology
  • Computational Biology

Background:

  • Dietary supplements (DS) information is fragmented across multiple resources.
  • Standardization is needed for efficient knowledge dissemination and utilization.
  • Existing DS databases lack comprehensive integration.

Purpose of the Study:

  • To develop a standardized, integrated knowledge base of dietary supplement (DS) information.
  • To create the integrated DIetary Supplement Knowledge base (iDISK).
  • To consolidate DS data from four distinct resources.

Main Methods:

  • An iterative process involving content scope establishment, data model development, and resource integration.
  • Integration of four key DS resources: Natural Medicines Comprehensive Database, Memorial Sloan Kettering's "About Herbs", Dietary Supplement Label Database, and Natural Health Products Database.
  • Manual evaluation of data extraction and integration accuracy for 50 randomly selected ingredients.

Main Results:

  • The iDISK knowledge base contains 4208 DS ingredient concepts linked to drugs, diseases, symptoms, and products.
  • The knowledge base includes 7 concept attribute types and 3 relationship attribute types.
  • Data extraction and integration demonstrated high accuracy with average errors of 0.3% for concepts, 2.6% for relationships, and 0.4% for attributes.

Conclusions:

  • iDISK is a publicly available, standardized knowledge base for dietary supplements.
  • The developed knowledge base facilitates efficient and meaningful dissemination of DS information.
  • iDISK serves as a valuable resource for researchers and healthcare professionals.