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Related Experiment Video

Updated: Dec 28, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

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Published on: August 30, 2018

Antimicrobial stewardship failure: time for a new model.

Cathal E O'Sullivan¹

¹Midland Regional Hospitals, Arden Road, Tullamore, Offaly, Ireland.

The Journal of Antimicrobial Chemotherapy

|February 19, 2020

Summary

Despite a national antimicrobial stewardship program, Ireland saw a 16% increase in antimicrobial consumption. A new model focusing on physician-specific data and education is proposed to improve antimicrobial stewardship and combat resistant infections.

Area of Science:

Public Health
Infectious Disease Epidemiology
Healthcare Management

Background:

Ireland has 10 years of national antimicrobial consumption data.
Existing antimicrobial stewardship programs have not curbed rising consumption.
Carbapenemase-producing Enterobacterales and Clostridioides difficile remain challenges in acute care.

Purpose of the Study:

To evaluate the effectiveness of the current national antimicrobial stewardship program.
To propose a new model for antimicrobial stewardship in Ireland.

Main Methods:

Analysis of 10 years of national antimicrobial consumption data.
Review of the current antimicrobial stewardship program's impact.
Proposal of a new stewardship model based on physician-specific data and education.

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Main Results:

National antimicrobial consumption increased by 16% over 10 years.
The current national antimicrobial stewardship program appears ineffective.
Persistent challenges with carbapenemase-producing Enterobacterales and Clostridioides difficile.

Conclusions:

A new model for antimicrobial stewardship is urgently needed.
Physician-specific consumption data and enhanced clinician education are key components of the proposed model.
Shifting towards self-regulation through transparency and peer pressure may improve antimicrobial prescribing practices.