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A questionnaire study on sleep disturbances associated with Prader-Willi syndrome

Thereza Lemos de Oliveira Queiroga1, Durval Damiani2, Maria Cecilia Lopes3

  • 1Pediatric Sleep Laboratory, Universidade de São Paulo Instituto da Criança, São Paulo, Brazil.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|February 19, 2020
PubMed

Insights

Children with Prader-Willi syndrome (PWS) experience more sleep breathing and sleep-initiation/maintenance issues. PWS is also linked to increased nighttime sweating, but the SDSC tool may not detect excessive daytime sleepiness in these patients.

Area of Science:

  • Pediatric Neurology
  • Sleep Medicine
  • Genetics

Background:

  • Prader-Willi syndrome (PWS) is a complex genetic disorder affecting multiple bodily functions.
  • Sleep disturbances are frequently reported in individuals with PWS, impacting quality of life.
  • Objective assessment of sleep issues in PWS is crucial for effective management.

Purpose of the Study:

  • To investigate the prevalence and types of sleep disturbances in children with PWS.
  • To compare sleep patterns in children with PWS to a control group.
  • To evaluate the association between PWS and hyperhidrosis during sleep.

Main Methods:

  • Utilized the Sleep Disturbance Scale for Children (SDSC) questionnaire.
  • Enrolled 50 children diagnosed with PWS.
  • Included 112 age- and sex-matched healthy children as controls.

Main Results:

  • Children with PWS exhibited significantly higher scores for sleep-disordered breathing and disorders in initiating and maintaining sleep compared to controls.
  • A notable association was found between PWS and hyperhidrosis (excessive sweating) during sleep.
  • No significant differences in hypersomnolence were observed between the PWS and control groups using the SDSC.

Conclusions:

  • Children with PWS frequently experience sleep-disordered breathing and difficulties initiating or maintaining sleep.
  • Hyperhidrosis during sleep is significantly associated with PWS.
  • The SDSC may have limitations in accurately identifying excessive daytime somnolence in children with PWS.

Keywords:
Prader-Willi syndromehyperhidrosisquestionnairesleep disordered breathingsleep disturbance scale for children

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