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From astrocytoma to glioblastoma: a clonal evolution study

Fuhua Yang1,2, Yunding Zou3, Qiang Gong3

  • 1Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, China.

FEBS Open Bio
|February 19, 2020
PubMed
Summary

Genetic analysis of astrocytoma recurrence reveals key mutations in TP53 and IDH1. These genetic changes, alongside treatment pressures, drive tumor evolution from lower-grade astrocytoma to glioblastoma.

Keywords:
TP53astrocytomaclonal evolutionglioblastomarelapse

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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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