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Updated: Dec 28, 2025

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

[C3 glomerulopathy and MPGN - current classification].

Bernd Hohenstein

Deutsche Medizinische Wochenschrift (1946)

|February 19, 2020

Summary

Membranoproliferative glomerulonephritis (MPGN) and C3 glomerulopathy (C3G) are rare kidney diseases with shared pathophysiology. Comprehensive analysis aids in identifying secondary causes and guides treatment for these progressive autoimmune disorders.

Area of Science:

Nephrology
Autoimmunology
Renal Pathology

Background:

Membranoproliferative glomerulonephritis (MPGN) and C3 glomerulopathy (C3G) are rare autoimmune kidney diseases, classified in 2010.
These conditions are now understood as a disease spectrum with overlapping pathophysiology, clinical course, and genetic factors.

Purpose of the Study:

To highlight the shared pathophysiological aspects between immune complex-associated MPGN (IC-MPGN) and C3G.
To emphasize the importance of identifying secondary causes through comprehensive diagnostic workups.

Main Methods:

Review of current scientific evidence on IC-MPGN and C3G pathophysiology.
Discussion of diagnostic approaches including histology, complement analysis, antibody screening, and human genetics.

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Main Results:

IC-MPGN and C3G share common pathophysiological mechanisms, including secondary causes, autoantibodies, and genetic predispositions.
Knowledge of these shared aspects is crucial for identifying secondary causes.

Conclusions:

Consistent and comprehensive diagnostic evaluation, including complement analysis, antibody screening, and genetic testing, is essential after histologic diagnosis.
Available therapeutic strategies can be applied to these rapidly progressive and relapsing renal diseases based on current evidence.