Related Experiment Video
Updated: Dec 28, 2025
13:53
The Helsinki Rat Microsurgical Sidewall Aneurysm Model
Published on: October 12, 2014
12.6K
Saccular Aneurysm Models Featuring Growth and Rupture: A Systematic Review
Serge Marbacher1,2, Stefan Wanderer1,2, Fabio Strange1,2
1Department of Neurosurgery, Kantonsspital Aarau, Aarau 5000, Switzerland.
Brain Sciences
|February 20, 2020
Summary
Rare extracranial saccular aneurysm models exhibit growth and rupture, often requiring aneurysm wall degradation. These models are crucial for preclinical testing of novel endovascular therapies.
Area of Science:
- Biomedical Engineering
- Vascular Surgery
- Preclinical Research
Background:
- Most large animal extracranial aneurysm models have stable pouches and heal well after endovascular treatment.
- A small subset of models exhibit aneurysm growth and potential rupture during follow-up.
- This review focuses on these rare, growth-prone extracranial aneurysm models.
Purpose of the Study:
- To identify and characterize in vivo extracranial saccular aneurysm models that demonstrate growth and rupture.
- To evaluate the potential of these models for preclinical testing of endovascular therapies.
Main Methods:
- Literature search in Medline/PubMed using PRISMA guidelines.
- Inclusion of studies on experimentally created extracranial saccular aneurysm models with growth/rupture.
- Extraction of data on aneurysm creation, characteristics, growth/rupture rates, histology, and outcomes.
Main Results:
- Twenty articles described growth and/or rupture in experimental extracranial saccular aneurysms.
- Growth was most frequent in rats, followed by swine, rabbits, and dogs.
- The highest growth rate (10-fold increase) was observed in a rat abdominal aortic sidewall aneurysm model.
Conclusions:
- Extracranial saccular aneurysm models with growth and rupture are uncommon.
- Aneurysm wall degradation appears necessary for growth and potential rupture.
- These models are valuable for preclinical evaluation of new endovascular treatments.
More Related Videos
Related Concept Videos
01:26Aneurysm III: Interprofessional Care
194
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
194
01:30Aneurysm I: Introduction
222
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
222
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
151
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
151