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Boron Chemistry for Medical Applications
Fayaz Ali1, Narayan S Hosmane2, Yinghuai Zhu1
1School of Pharmacy, Macau university of Science and Technology, Avenida Wai Long Taipa, Macau 999078, China.
Molecules (Basel, Switzerland)
|February 20, 2020
Summary
Boron compounds offer new avenues in medicinal chemistry, particularly for boron neutron capture therapy (BNCT). Advancements in boron-based agents show promise for improved cancer treatment efficacy.
Area of Science:
- Medicinal Chemistry
- Organometallic Chemistry
- Oncology
Background:
- Boron compounds have diverse applications, yet their pharmaceutical use remains limited despite decades of recognition.
- Carboranes, metallacarboranes, and metallaboranes represent key classes of boron compounds with significant medicinal chemistry interest.
- Existing boron delivery agents for boron neutron capture therapy (BNCT) require enhancement for optimal clinical application.
Purpose of the Study:
- To review advancements in boron-containing compounds for medicinal chemistry applications.
- To highlight the clinical potential of novel boron-based compounds for boron neutron capture therapy (BNCT).
- To focus on boron compounds demonstrating in vivo and/or in vitro efficacy for cancer treatment.
Main Methods:
- Literature review of recent advancements in boron-containing compounds.
- Analysis of boron compounds, including carboranes, metallacarboranes, and metallaboranes.
- Evaluation of in vitro and in vivo efficacy data for potential BNCT agents.
Main Results:
- Recent developments showcase promising new boron-based compounds for medicinal chemistry.
- Several boron compounds exhibit significant in vitro and/or in vivo efficacy.
- Advancements are being made in developing improved localized delivery agents for BNCT.
Conclusions:
- Boron compounds represent a novel class of agents with substantial potential in drug design.
- Improved boron-based compounds are crucial for realizing the full clinical potential of BNCT.
- Further research into these compounds could lead to more effective cancer therapies.
