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Related Experiment Videos

Age-related auditory brainstem response (ABR) threshold changes in the dancer mouse mutant.

B I Wenngren1, M Anniko

  • 1Department of Oto-Rhino-Laryngology, University Hospital, Umeå, Sweden.

Acta Oto-Laryngologica
|November 1, 1988
PubMed
Summary

Auditory brainstem response (ABR) thresholds in dancer mice worsen with age, showing progressive hearing loss from the second month. This study analyzes the age-related auditory defects in these mutants.

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Area of Science:

  • Neuroscience
  • Genetics
  • Auditory Science

Background:

  • The dancer mouse mutant exhibits a morphogenetic inner ear defect.
  • This defect is attributed to a semidominant gene on chromosome 19.

Purpose of the Study:

  • To investigate the age-related changes in auditory brainstem response (ABR) thresholds in heterozygotic dancer mouse mutants.
  • To characterize the progressive hearing impairment associated with the dancer mutation.

Main Methods:

  • Auditory brainstem response (ABR) threshold measurements were conducted on 42 heterozygotic dancer mouse mutants aged 1-13 months.
  • Comparative analysis was performed against normal CBA/CBA mice.

Main Results:

  • A significant impairment of ABR thresholds was observed with increasing age in dancer mutants.

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  • Progressive deterioration of ABR thresholds began from the second postnatal month compared to controls.
  • Individual threshold curves exhibited considerable variability.

    • Conclusions:

    • The dancer mutation leads to age-dependent auditory dysfunction.
    • Early postnatal development is critical for the onset of hearing impairment in this model.
    • The dancer mouse serves as a valuable model for studying age-related hearing loss with a genetic basis.