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Updated: Dec 28, 2025

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
Published on: August 18, 2020
Guided web-based treatment program for reducing cannabis use: a randomized controlled trial.
Kristina Sinadinovic1, Magnus Johansson2,3, Ann-Sofie Johansson4
1Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
This study found that a therapist-guided, web-based program did not significantly reduce cannabis use frequency in adults and adolescents. Adherence to the intervention showed some association with reduced cannabis abuse symptoms.
Area of Science:
- Psychiatry
- Psychology
- Public Health
Background:
- Regular cannabis use is a concern in the general population, affecting both adults and adolescents.
- Web-based interventions offer a potential avenue for treatment delivery.
- Therapist guidance may enhance the efficacy of digital health interventions.
Purpose of the Study:
- To evaluate the effectiveness of a therapist-guided, web-based treatment program for individuals with regular cannabis use.
- To assess the impact of the intervention on the frequency of cannabis consumption.
- To explore the relationship between intervention adherence and treatment outcomes.
Main Methods:
- A double-blind, randomized controlled trial with a parallel group design was employed.
- 151 participants were in the intervention group and 152 in the wait-list control group.
- The primary outcome was the frequency of cannabis use, measured over 12 weeks.
Main Results:
- Intention-to-treat analyses showed no significant difference in cannabis use frequency between groups.
- Intervention adherence was significantly associated with scores on the Cannabis Abuse Screening Test (CAST).
- Secondary analyses suggested potential benefits for specific outcomes, but these require cautious interpretation due to limitations.
Conclusions:
- The therapist-guided web-based program was not more effective than a waiting-list condition in reducing cannabis use frequency.
- Further research may be needed to optimize web-based interventions for cannabis use disorder.
- The study highlights the complexity of evaluating digital mental health interventions.
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