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Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Updated: Dec 28, 2025

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Infections in patients diagnosed with multiple sclerosis: A multi-database study.

R Persson1, S Lee2, M Ulcickas Yood3

  • 1Boston Collaborative Drug Surveillance Program, Lexington, MA, USA.

Multiple Sclerosis and Related Disorders
|February 20, 2020
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) patients face a higher risk of infections, particularly kidney and urinary tract infections, and a doubled risk of hospitalization due to infections compared to individuals without MS.

Keywords:
EpidemiologyInfectionsMultiple sclerosisOpportunistic infections

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Epidemiology

Background:

  • Limited recent data exists on infection rates in multiple sclerosis (MS) patients.
  • This study aims to quantify infection incidence in MS patients versus a matched non-MS cohort.

Purpose of the Study:

  • To compare infection incidence rates between patients with multiple sclerosis (MS) and matched controls without MS.
  • To identify specific types and sites of infection that are more prevalent in MS patients.

Main Methods:

  • Utilized two large electronic health databases: US-DOD and UK-CPRD.
  • Identified MS patients and matched non-MS controls diagnosed between 2001-2017.
  • Calculated incidence rates and rate ratios for various infections post-diagnosis.

Main Results:

  • MS patients exhibited higher rates of any infection (IRR 1.25-1.76) and a two-fold higher rate of hospitalized infections (IRR 2.00-2.43).
  • Urinary tract/kidney infections were nearly doubled in MS patients (IRR 1.88-1.97).
  • Opportunistic infections, candidiasis, and herpes virus infections were also increased in MS patients.

Conclusions:

  • Multiple sclerosis patients have a significantly increased risk of infections.
  • Notably, MS patients face higher risks for renal tract infections and a doubled risk for hospitalized infections.