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Cordocentesis: an appraisal of risks.
B W Pielet1, M L Socol, S N MacGregor
1Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Illinois.
American Journal of Obstetrics and Gynecology
|December 1, 1988
Summary
Fetal blood sampling via cordocentesis is increasingly common. While generally safe with low complication rates, careful patient selection and expert performance at specialized centers are crucial for optimal outcomes.
Area of Science:
- Perinatology
- Maternal-Fetal Medicine
- Diagnostic Ultrasound
Background:
- Fetal blood sampling via cordocentesis is a frequently utilized prenatal diagnostic procedure.
- Increasing frequency necessitates a review of its safety and efficacy.
Purpose of the Study:
- To evaluate the complication and mortality rates associated with ultrasonography-guided cordocentesis.
- To assess the safety profile of intravascular transfusions performed concurrently.
Main Methods:
- Prospective study of 58 intravascular transfusions and 27 fetal blood samplings over 24 months.
- Procedures guided by ultrasonography.
- Complication and mortality rates meticulously recorded.
Main Results:
- Fetal blood sampling had a complication rate of 7.1% (2/28) and 0% procedure-related mortality.
- Intravascular transfusions had a complication rate of 9.4% (6/64) and a 4.7% (3/64) procedure-related mortality.
- Ultrasonography guidance was employed for all procedures.
Conclusions:
- Cordocentesis is associated with low complication and mortality rates when performed by skilled personnel.
- Careful patient selection and performance in tertiary care centers are recommended.
- Expertise in ultrasonography and prenatal diagnosis is essential for safe cordocentesis.