Association Between Serum Testosterone and Serum PSA Among Men With and Without Partial Androgen Deficiency

Area of Science:

• Urology
• Endocrinology
• Andrology

Background:

• The relationship between serum prostate-specific antigen (PSA) and serum testosterone remains unclear, with conflicting research findings.
• Partial androgen deficiency in aging males (PADAM) is a condition characterized by low testosterone levels.

Purpose of the Study:

• To investigate the association between serum PSA and serum testosterone levels in healthy men and those with PADAM.
• To determine if testosterone levels influence PSA values in men over 50.

Main Methods:

• A cross-sectional study involving 255 men aged over 50.
• Serum testosterone, PSA, and Aging Male Symptom (AMS) scores were measured.
• Participants were categorized into groups with and without PADAM.

Main Results:

• Mean total testosterone was 9.35 ± 1.33 nmol/L with PADAM and 15.30 ± 1.95 nmol/L without PADAM.
• Mean serum PSA was 1.96 ± 0.76 ng/mL with PADAM and 1.85 ± 0.73 ng/mL without PADAM.
• No significant correlation was found between serum PSA and serum testosterone levels in either group.

Conclusions:

• Serum PSA and serum testosterone levels are not significantly related in men over 50, even in the presence of PADAM.
• PSA values do not require adjustment based on testosterone levels when making prostate biopsy decisions.