Interactions between Plasmodium yoelii and Leishmania mexicana amazonensis in Leishmania resistant C57B1/6 mice

We examined the effect of concurrent infection with Plasmodium yoelii and Leishmania mexicana amazonensis on the course of each disease in leishmania resistant C57Bl/6 mice. P. yoelii parasitemia was greatly enhanced when L. m. amazonensis was inoculated 2 days, 3 weeks, or 12 weeks prior to the malaria. Lesions due to L. m. amazonensis were enhanced in mice concomitantly infected with P. yoelii compared to mice infected with L. m. amazonensis only. Metastatic L. m. amazonensis lesions developed in mice infected with P. yoelii and L. m. amazonensis, but never in mice only infected with L. m. amazonensis.