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Onychomycosis caused by Pichia guilliermondii: A case report and mini-review

Mei-Jie Zhang1, Guan-Zhao Liang1, Huan Mei1

  • 1Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, 12th JiangWangMiao Street, Nanjing, Jiangsu, 210029, China.

Medical Mycology Case Reports
|February 20, 2020
PubMed

Insights

This study reports a rare case of fingernail onychomycosis caused by Pichia guilliermondii, a yeast species. Treatment with itraconazole showed positive results, suggesting a potential therapeutic option for this specific type of nail infection.

Area of Science:

  • Medical Mycology
  • Dermatology

Background:

  • Onychomycosis is predominantly caused by dermatophytes.
  • Yeast, particularly Candida species, are increasingly recognized as causative agents of onychomycosis.
  • Fungal nail infections require effective and targeted treatments.

Observation:

  • A case of fingernail onychomycosis was observed.
  • The causative agent was identified as Pichia guilliermondii, the sexual stage of Candida guilliermondii.
  • This represents a potentially novel etiology for onychomycosis.

Findings:

  • The patient presented with a fingernail infection.
  • Treatment involved three courses of itraconazole.
  • Significant improvement in the onychomycosis was achieved without adverse effects.

Implications:

  • Pichia guilliermondii can cause onychomycosis.
  • Itraconazole appears effective for treating Pichia guilliermondii onychomycosis.
  • This case highlights the importance of identifying non-dermatophyte molds and yeasts in nail infections.
Keywords:
CandidaItraconazoleOnychomycosisPichia guilliermondii

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