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Related Experiment Video

Updated: Dec 28, 2025

Real-time Monitoring of High Intensity Focused Ultrasound HIFU Ablation of In Vitro Canine Livers Using Harmonic Motion Imaging for Focused Ultrasound HMIFU

Real-time Monitoring of High Intensity Focused Ultrasound HIFU Ablation of In Vitro Canine Livers Using Harmonic Motion Imaging for Focused Ultrasound HMIFU

Published on: November 3, 2015

Spatially compounded plane wave imaging using a laser-induced ultrasound source.

David Thompson¹, Damien Gasteau^1,2, Srirang Manohar^1,2

¹Biomedical Photonic Imaging, Technical Medical Centre, University of Twente, The Netherlands.

|February 20, 2020

Summary

This study introduces laser-induced ultrasound for improved medical imaging. This novel plane wave imaging technique enhances tumor contrast by 55% compared to conventional methods.

Keywords:

Carbon black Laser-induced ultrasound PDMS Phantom Plane wave imaging Spatial compounding

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Last Updated: Dec 28, 2025

Real-time Monitoring of High Intensity Focused Ultrasound HIFU Ablation of In Vitro Canine Livers Using Harmonic Motion Imaging for Focused Ultrasound HMIFU

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Multiplexing Focused Ultrasound Stimulation with Fluorescence Microscopy

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Published on: January 7, 2019

Area of Science:

Biomedical Engineering
Medical Imaging
Acoustics

Background:

Conventional ultrasound imaging faces limitations in contrast resolution and image homogeneity.
Plane wave imaging offers faster acquisition but can suffer from reduced image quality.

Purpose of the Study:

To develop and evaluate a novel spatially compounded plane wave imaging system utilizing a laser-induced ultrasound source.
To compare the performance of laser-induced ultrasound imaging against conventional ultrasound methods.

Main Methods:

Fabrication of a laser-induced ultrasound plane wave source using carbon black-doped PDMS and a polyester substrate.
Integration of the laser source with a linear ultrasound array for simultaneous insonification and detection.
Imaging of wire phantoms and a tissue-mimicking phantom to assess image quality and contrast.

Main Results:

Laser-induced ultrasound imaging demonstrated a more homogeneous point-spread function across the imaging plane compared to conventional ultrasound.
A 55% improvement in contrast was observed between a simulated tumor and background tissue using the laser-induced method.
Lateral resolution was comparable, with a slight advantage for conventional ultrasound in specific phantom tests.

Conclusions:

Laser-induced plane wave ultrasound imaging is a promising technique for enhancing contrast in medical ultrasound.
The developed system offers a viable alternative to conventional ultrasound, particularly for applications requiring improved visualization of subtle tissue differences.