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Cerebellar Deep Brain Stimulation for Acquired Hemidystonia
Ethan G Brown1, Ian O Bledsoe1, Nijee S Luthra1
1Movement Disorders and Neuromodulation Center, Department of Neurology University of California San Francisco San Francisco California USA.
Background:
The cerebellum's role in dystonia is increasingly recognized. Dystonia can be a disabling and refractory condition; deep brain stimulation can help many patients, but it is traditionally less effective in acquired dystonia. New surgical targets would be instrumental in providing treatment options and understanding dystonia further.
Objective:
To evaluate the efficacy of deep brain stimulation of the cerebellum in acquired dystonia.
Methods:
We report our management of a 37-year-old woman with severe left arm and leg dystonia, a complication of an ischemic stroke in childhood. She had already had 2 thalamotomies with only transient benefit. These procedures, in addition to her initial stroke that had damaged the basal ganglia, left traditional deep brain stimulation targets unavailable.
Results:
After implantation of bilateral deep cerebellar nuclei, dystonia improved with a 40% reduction in severity on scales and subjective reports of improved posturing, gait, and pain. This improvement has been maintained for almost 2 years after implantation.
Conclusion:
Cerebellar stimulation has potential for therapeutic benefit in acquired dystonia and should be further explored.
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