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Updated: Dec 28, 2025

Electrophysiological Measurements and Analysis of Nociception in Human Infants
Published on: December 20, 2011
Pediatric pain treatment and prevention for hospitalized children
Stefan J Friedrichsdorf1,2,3, Liesbet Goubert4
1Center of Pain Medicine, Palliative Care and Integrative Medicine, University of California at San Francisco (UCSF), Benioff Children's Hospitals in Oakland and San Francisco, CA, USA.
Insights
Effective pain management for children is crucial, especially for needle procedures. Implementing multimodal analgesia and evidence-based strategies ensures better outcomes for pediatric patients experiencing acute or chronic pain.
Area of Science:
- Pediatric Pain Management
- Evidence-Based Medicine
- Clinical Practice Guidelines
Background:
- Pediatric pain prevention and treatment are often inadequate, particularly in younger children.
- Children aged 0-17 represent a vulnerable population requiring specialized pain care.
- Current practices frequently fall short of optimal pain management standards for children.
Purpose of the Study:
- To outline strategies for preventing and treating acute and chronic pain in children.
- To provide recommendations for managing pain associated with needle-based procedures.
- To establish recommended starting doses for analgesics in pediatric populations.
Main Methods:
- Review of the 2019 IASP Global Year Against Pain in the Vulnerable "Factsheet Pain in Children: Management".
- Synthesis of best available evidence and clinical practices for pediatric pain management.
- Elaboration on multimodal approaches for pain control in children.
Main Results:
- Multimodal analgesia (pharmacology, regional anesthesia, psychological, spiritual, integrative modalities) offers synergistic benefits for acute pediatric pain.
- An interdisciplinary rehabilitative approach is most effective for chronic pediatric pain.
- A bundle of four modalities (topical anesthesia, comfort positioning, sucrose/breastfeeding, distraction) is recommended for all elective needle procedures in children.
Conclusions:
- Failure to implement evidence-based pain management for children is unacceptable.
- Inadequate pain management in pediatric patients constitutes poor standard of care.
- Adherence to best practices in pediatric pain prevention and treatment is essential.
Introduction:
Prevention and treatment of pain in pediatric patients compared with adults is often not only inadequate but also less often implemented the younger the children are. Children 0 to 17 years are a vulnerable population.
Objectives:
To address the prevention and treatment of acute and chronic pain in children, including pain caused by needles, with recommended analgesic starting doses.
Methods:
This Clinical Update elaborates on the 2019 IASP Global Year Against Pain in the Vulnerable "Factsheet Pain in Children: Management" and reviews best evidence and practice.
Results:
Multimodal analgesia may include pharmacology (eg, basic analgesics, opioids, and adjuvant analgesia), regional anesthesia, rehabilitation, psychological approaches, spirituality, and integrative modalities, which act synergistically for more effective acute pediatric pain control with fewer side effects than any single analgesic or modality. For chronic pain, an interdisciplinary rehabilitative approach, including physical therapy, psychological treatment, integrative mind-body techniques, and normalizing life, has been shown most effective. For elective needle procedures, such as blood draws, intravenous access, injections, or vaccination, overwhelming evidence now mandates that a bundle of 4 modalities to eliminate or decrease pain should be offered to every child every time: (1) topical anesthesia, eg, lidocaine 4% cream, (2) comfort positioning, eg, skin-to-skin contact for infants, not restraining children, (3) sucrose or breastfeeding for infants, and (4) age-appropriate distraction. A deferral process (Plan B) may include nitrous gas analgesia and sedation.
Conclusion:
Failure to implement evidence-based pain prevention and treatment for children in medical facilities is now considered inadmissible and poor standard of care.
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