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Updated: Dec 28, 2025

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
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CD32a polymorphism rs1801274 affects the risk of Kawasaki disease

Zhiyong Wang1, Pei-Liang Geng2

  • 1Department of Pediatrics, Weifang Maternal and Child Health Hospital, Weifang, China.

Artificial Cells, Nanomedicine, and Biotechnology
|February 20, 2020
PubMed

Insights

The CD32a polymorphism rs1801274 significantly increases the risk of Kawasaki disease (KD). The presence of the A allele in this gene variant is associated with a higher incidence of KD, particularly in certain ethnic groups.

Area of Science:

  • Genetics
  • Immunology
  • Pediatrics

Background:

  • Kawasaki disease (KD) is an acute febrile vasculitis affecting young children.
  • Genetic factors are implicated in KD susceptibility, but specific gene associations require further investigation.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the association between CD32a polymorphism rs1801274 and Kawasaki disease risk.
  • To assess the impact of this polymorphism across different ethnicities and control sources.

Main Methods:

  • Meta-analysis of published studies examining the CD32a polymorphism rs1801274 and KD susceptibility.
  • Calculation of summarized odds ratios (ORs) with 95% confidence intervals (CIs).
  • Stratification analyses by ethnicity and control source, heterogeneity testing, sensitivity analysis, and publication bias assessment.

Main Results:

  • CD32a polymorphism rs1801274 significantly elevated KD risk across multiple genetic comparisons (e.g., AA vs. GG, A vs. G).
  • The association remained consistent in subgroup analyses stratified by ethnicity (Caucasian, Asian) and control source (population-based, other).
  • The A allele of CD32a rs1801274 was linked to increased disease incidence.

Conclusions:

  • CD32a polymorphism rs1801274 is strongly associated with the onset of Kawasaki disease.
  • The A allele of CD32a rs1801274 is a risk factor for developing KD.

Keywords:
CD32aFcγ receptorFcγRIIAKawasaki diseasepolymorphism

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