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Updated: Dec 28, 2025

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Beating the ER: novel insights into FAM134B function and regulation

Chiara De Leonibus1, Laura Cinque1, Carmine Settembre1,2

  • 1Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.

The EMBO Journal
|February 20, 2020
PubMed
Summary

Endoplasmic reticulum (ER) degradation, known as ER-phagy, requires receptor FAM134B to fragment ER membranes. This process, driven by CAMK2B phosphorylation, is crucial for cellular homeostasis and is implicated in sensory neuropathy.

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