Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of domain-specific probes of <i>Plasmodium falciparum</i> heat shock protein 70-1.

Antimicrobial agents and chemotherapy·2026
Same author

Loss of O-antigen due to <i>wbbL</i> mutations is common and associated with increased mortality in <i>Escherichia coli</i> bloodstream infections.

Science advances·2026
Same author

Hyperpolarized <sup>15</sup>N<sub>2</sub>-Diazirine-Tagged MRI Probe for Monitoring γ-Glutamyl Transferase Activity.

ACS sensors·2026
Same author

A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics.

Nature microbiology·2025
Same author

Host sphingolipids support <i>Plasmodium berghei</i> liver stage development.

mBio·2025
Same author

A host-directed adjuvant resuscitates and sensitizes intracellular bacterial persisters to antibiotics.

bioRxiv : the preprint server for biology·2024

Related Experiment Video

Updated: Dec 28, 2025

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
07:14

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

468

Tafenoquine: A Step toward Malaria Elimination.

Kuan-Yi Lu1, Emily R Derbyshire1,2

  • 1Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, North Carolina 27708, United States.

Biochemistry
|February 20, 2020
PubMed
Summary

Tafenoquine is a new drug for malaria, effective against dormant parasites. Further research is needed to understand its mechanisms and improve its therapeutic index for better malaria treatment.

More Related Videos

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors
05:28

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

Published on: May 12, 2022

3.5K
Detection and Quantification of Plasmodium falciparum in Aqueous Red Blood Cells by Attenuated Total Reflection Infrared Spectroscopy and Multivariate Data Analysis
10:50

Detection and Quantification of Plasmodium falciparum in Aqueous Red Blood Cells by Attenuated Total Reflection Infrared Spectroscopy and Multivariate Data Analysis

Published on: November 2, 2018

8.3K

Related Experiment Videos

Last Updated: Dec 28, 2025

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
07:14

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

468
Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors
05:28

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

Published on: May 12, 2022

3.5K
Detection and Quantification of Plasmodium falciparum in Aqueous Red Blood Cells by Attenuated Total Reflection Infrared Spectroscopy and Multivariate Data Analysis
10:50

Detection and Quantification of Plasmodium falciparum in Aqueous Red Blood Cells by Attenuated Total Reflection Infrared Spectroscopy and Multivariate Data Analysis

Published on: November 2, 2018

8.3K

Area of Science:

  • Malariology
  • Medicinal Chemistry
  • Parasitology

Background:

  • Malaria elimination requires targeting dormant liver-stage hypnozoites, responsible for relapses.
  • Tafenoquine, an 8-aminoquinoline, was approved in 2018 for radical cure of Plasmodium vivax malaria.
  • Understanding tafenoquine's mechanisms of action and adverse effects is crucial despite its efficacy.

Purpose of the Study:

  • To explore the plausible mechanisms of tafenoquine's antiparasitic activity.
  • To highlight tafenoquine's role as a cellular stressor.
  • To discuss strategies for improving tafenoquine's therapeutic index.

Main Methods:

  • Literature review and analysis of existing data on 8-aminoquinolines.
  • Discussion of potential drug combinations.
  • Exploration of next-generation 8-aminoquinoline development.

Main Results:

  • Tafenoquine exhibits broad-spectrum activity against various Plasmodium life stages.
  • Its long half-life enables single-dose treatment, improving patient compliance.
  • Plausible mechanisms suggest tafenoquine acts as a cellular stressor.

Conclusions:

  • Tafenoquine is a promising drug for radical malaria cure, particularly P. vivax.
  • Further research into its mechanisms and potential adverse effects is warranted.
  • Drug combinations and next-generation analogs may enhance therapeutic outcomes.