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Extracorporeal Therapies in the Treatment of Focal Segmental Glomerulosclerosis

Rupesh Raina1,2, Joseph Wang3, Aditya Sharma4

  • 1Department of Pediatric Nephrology, Akron Children's Hospital, Akron, Ohio, USA, rraina@akronchildrens.org.

Blood Purification
|February 20, 2020
PubMed

Insights

Focal segmental glomerulosclerosis (FSGS) is a severe kidney disease. Extracorporeal therapies like plasma exchange show promise for treating drug-resistant pediatric FSGS when other treatments fail.

Area of Science:

  • Nephrology
  • Pediatric Nephrology
  • Renal Medicine

Background:

  • Focal segmental glomerulosclerosis (FSGS) is a leading cause of severe glomerular kidney disease.
  • FSGS frequently progresses to end-stage renal disease and recurs post-transplant.
  • Current immunomodulatory treatments for FSGS are often ineffective or poorly tolerated.

Purpose of the Study:

  • To review the current literature on extracorporeal therapies for pediatric FSGS.
  • To evaluate the efficacy of these therapies in managing drug-resistant and recurrent FSGS.
  • To highlight potential benefits of extracorporeal treatments in pediatric FSGS management.

Main Methods:

  • Literature review of studies on extracorporeal therapies for FSGS in children.
  • Analysis of data concerning plasma exchange therapy, immunoadsorption, and LDL apheresis.
  • Assessment of treatment outcomes in pediatric FSGS patients.

Main Results:

  • Extracorporeal therapies demonstrate potential benefits in select pediatric FSGS cases.
  • Evidence suggests efficacy in managing FSGS resistant to standard treatments.
  • These methods offer alternatives for recurrent FSGS post-transplantation.

Conclusions:

  • Extracorporeal therapies represent a promising therapeutic avenue for pediatric FSGS.
  • Further research is warranted to establish optimal protocols for these treatments.
  • These advanced therapies may improve outcomes for children with challenging FSGS cases.
Keywords:
Extracorporeal therapyFocal segmental glomerulosclerosisImmunoadsorptionLow-density lipoprotein apheresisPlasma exchange

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