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Related Experiment Video

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[Experimental study on the effect of olfactory training on olfactory function in mice with olfactory dysfunction].

J H Zhou1, D Xing, H M Ma

  • 1Department of Otorhinolaryngology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China.

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Chinese Journal of Otorhinolaryngology Head and Neck Surgery
|February 20, 2020
PubMed
Summary

Olfactory training aids recovery in mice with smell loss induced by 3-methylindole (3-MI). This training accelerated olfactory function recovery, as shown by reduced food-finding times and improved olfactory marker protein (OMP) levels.

Keywords:
3-methylindoleModels, animalOlfactory disordersOlfactory training

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Area of Science:

  • Neuroscience
  • Olfactory Research
  • Animal Models

Background:

  • Olfactory dysfunction can significantly impact quality of life.
  • 3-methylindole (3-MI) is a chemical agent used to induce olfactory dysfunction in animal models.
  • Understanding recovery mechanisms is crucial for developing therapeutic strategies.

Purpose of the Study:

  • To investigate the efficacy of olfactory training in mice with 3-methylindole-induced olfactory dysfunction.
  • To assess the impact of olfactory training on olfactory function recovery and related biomarkers.

Main Methods:

  • Thirty-one male BALB/c mice were divided into control, olfactory dysfunction, and olfactory dysfunction with training groups.
  • Olfactory dysfunction was induced using intraperitoneal injection of 3-MI.
  • Olfactory training involved daily inhalation of various odors for 28 days.
  • Behavioral tests (buried food pellet test) and histological analysis (OMP expression, olfactory epithelium thickness) were performed.

Main Results:

  • Mice undergoing olfactory training showed significantly shorter food-finding times compared to the untreated olfactory dysfunction group.
  • Olfactory training group exhibited higher olfactory marker protein (OMP) expression and thicker olfactory epithelium compared to the untreated group.
  • A significant negative correlation was observed between OMP expression and food-finding time.

Conclusions:

  • Olfactory training effectively accelerates the recovery of olfactory function in mice with 3-MI-induced olfactory impairment.
  • The study highlights the potential of olfactory training as a therapeutic intervention for olfactory disorders.
  • Restoration of OMP expression and olfactory epithelium thickness are key indicators of functional recovery.