Related Experiment Video
Updated: Dec 28, 2025
07:32
Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
Published on: September 30, 2019
8.1K
Phage Display-Based Nanotechnology Applications in Cancer Immunotherapy
Martina Goracci1,2, Ymera Pignochino2, Serena Marchiò1,2
1Department of Oncology, University of Torino, 10060 Candiolo, Italy.
Molecules (Basel, Switzerland)
|February 21, 2020
Summary
Phage display technology offers novel peptide mimics of cancer antigens and phage particles for immunotherapy vaccines. These nanosized tools show promise in preclinical cancer immunotherapy studies.
Area of Science:
- Nanotechnology
- Immunology
- Oncology
Background:
- Phage display, a Nobel Prize-winning nanotechnology, enables high-affinity ligand isolation for diverse targets.
- Cancer immunotherapy is a rapidly advancing field with significant therapeutic potential.
Purpose of the Study:
- To review literature on peptide phage display applications in cancer immunotherapy.
- To highlight key outcomes and the potential of phage display in cancer treatment.
Main Methods:
- Literature review of studies applying peptide phage display to cancer immunotherapy.
- Analysis of phage display-derived peptides as cancer antigen mimics (mimotopes).
- Examination of antigen-carrying phage particles as vaccines and peptides as immune cell modulators.
Main Results:
- Phage display yields peptides mimicking cancer antigens (mimotopes).
- Antigen-carrying phage particles can serve as prophylactic and therapeutic vaccines.
- Phage display-derived peptides can modulate immune cell functions.
Conclusions:
- Preclinical studies demonstrate the efficacy of phage display in cancer immunotherapy.
- Phage display offers nanosized tools with vast potential for clinical cancer treatment.
- The clinical application of these phage display technologies is advancing.
Related Concept Videos
01:27Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
01:30Cancer Vaccines
880
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
880
02:57Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
01:29Microorganisms in Medicine and Therapeutics
861
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
861