Related Experiment Video

Updated: Dec 28, 2025

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

2.9K

Bioactive Phenolic Compounds in the Modulation of Central and Peripheral Nervous System Cancers: Facts and Misdeeds

Lorena Perrone1,2, Simone Sampaolo1, Mariarosa Anna Beatrice Melone1,3

  • 1Department of Advanced Medical and Surgical Sciences, 2nd Division of Neurology, Center for Rare Diseases and InterUniversity Center for Research in Neurosciences, University of Campania "Luigi Vanvitelli", Via Sergio Pansini, 5 80131 Naples, Italy.

Cancers
|February 21, 2020
PubMed

Insights

Polyphenols show promise for treating nervous system tumors but face absorption challenges. Nanoparticle delivery enhances their bioavailability and targeted delivery for improved efficacy in glioma and peripheral nerve sheath tumor treatment.

Area of Science:

  • Neuro-oncology
  • Pharmacology
  • Biotechnology

Background:

  • Gliomas, glioneuronal tumors, and peripheral nervous system (PNS) neoplasms lack effective cures.
  • Oxidative stress and metabolic dysregulation are implicated in nervous system tumor development.
  • Polyphenols possess antioxidant and anti-inflammatory properties beneficial for cancer prevention and therapy.

Purpose of the Study:

  • To review polyphenols for nervous system tumor prevention and treatment.
  • To highlight limitations in clinical application, including poor bioavailability and blood-brain barrier (BBB) penetration.
  • To explore strategies for enhancing polyphenol delivery and efficacy.

Main Methods:

  • Review of recent findings on polyphenol applications in nervous system tumors.
  • Analysis of challenges associated with polyphenol absorption and BBB crossing.
  • Examination of nanoparticle-based delivery systems for improved polyphenol bioavailability.

Main Results:

  • Polyphenols demonstrate potential in preventing and treating central nervous system (CNS) and PNS tumors.
  • Poor intestinal absorption, low bioavailability, and limited BBB penetration hinder clinical use.
  • Polymeric nanoparticle delivery systems show promise in overcoming these limitations.

Conclusions:

  • Nanoparticle-based polyphenol delivery enhances gastrointestinal absorption and bioavailability.
  • Targeted delivery strategies are crucial for improving polyphenol efficacy against nervous system tumors.
  • Further research is needed to optimize these strategies for clinical application.
Keywords:
bioavailabilitybrain cancergliomasmalignant tumors of the peripheral nerve sheath (MPNST)nanoparticle-based delivery systemsneurofibromaspolyphenolsschwannomas

More Related Videos

Establishing In Vitro Models of Dorsal Root Ganglia Culture: Complementary Approaches for Investigating Cancer-Nerve Crosstalk11:26

Establishing In Vitro Models of Dorsal Root Ganglia Culture: Complementary Approaches for Investigating Cancer-Nerve Crosstalk

Published on: July 11, 2025

1.3K
Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

6.3K

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
476
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
366
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.5K
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
737
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.8K