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Related Experiment Videos

Volume limitations of plasmapheresis.

P Lundsgaard-Hansen

    Vox Sanguinis
    |January 1, 1977
    PubMed
    Summary

    Plasmapheresis donors should not exceed 10-15 liters of plasma annually. This recommendation protects donors from prolonged deviations from normal health, ensuring safety in plasma donation procedures.

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    Area of Science:

    • Medical Science
    • Physiology
    • Immunology

    Background:

    • Plasmapheresis involves plasma removal, with significant international variation in annual donation limits.
    • Current guidelines range from 10-15 liters/year in Europe to 50-60 liters/year in the US.
    • Understanding the impact on serum proteins and albumin metabolism is crucial for donor safety.

    Purpose of the Study:

    • To determine appropriate annual plasma volume limits for plasmapheresis donors.
    • To evaluate the physiological effects of plasmapheresis on serum protein levels.
    • To ensure donor safety by preventing prolonged physiological deviations.

    Main Methods:

    • Comparative analysis of international plasmapheresis guidelines.
    • Review of literature on serum protein levels and albumin metabolism post-plasmapheresis.
    • Consideration of safeguards for whole blood donation and nephrotic syndrome.

    Main Results:

    • European guidelines (10-15 liters/year) are deemed more appropriate than US guidelines (50-60 liters/year).
    • Excessive plasmapheresis can lead to prolonged deviations from the normal physiological state.
    • Recommendations include limiting sessions to 500 ml with at least a 2-week interval.

    Conclusions:

    • Plasmapheresis donors should adhere to a maximum annual limit of 10-15 liters.
    • Individual donor safety requires strict limits on plasma volume withdrawn per session and between sessions.
    • European recommendations provide a safer model for plasmapheresis practices.

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