Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Sexually Transmitted Infections

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...

Endocarditis I: Introduction

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...

Pericarditis I: Introduction

Pericarditis I: Introduction

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...

Tonsillitis I: Introduction

Tonsillitis I: Introduction

Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.

Papillary Dermis

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Healing Strides: The Effectiveness of a Combined Grief Group Counseling and 5K Race Training Intervention on Grief-Related Symptoms.

Omega·2026

Same author

CLEAR: Comparative Letter Examination and Analysis for Red Flags.

Journal of graduate medical education·2026

Same author

Inside Their Minds: A Multi-Institutional Exploration into the Decision-Making of Medical School Competency Committee Members.

Perspectives on medical education·2026

Same author

Coupled catastrophes in systems with bidirectional feedback.

Chaos (Woodbury, N.Y.)·2025

Same author

The United States Withdrawal From the World Health Organization: Implications and Challenges.

International journal of health policy and management·2025

Same author

Introduction to focus issue: Topics in nonlinear science.

Chaos (Woodbury, N.Y.)·2025

Search research articles

Related Experiment Video

Updated: Dec 28, 2025

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

Published on: March 8, 2012

Incipient Syphilitic Papillitis.

John J Chen^1,2, M Tariq Bhatti^1,2, Elizabeth Bradley¹

¹Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA.

Neuro-Ophthalmology (Aeolus Press)

|February 21, 2020

Summary

Syphilis can cause optic disc edema (ODE) without vision loss. Researchers propose "incipient syphilitic papillitis" for this presentation, differentiating it from optic perineuritis.

Keywords:

Syphilis optic perineuritis papillitis

More Related Videos

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering

Published on: January 24, 2025

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Published on: March 1, 2024

Related Experiment Videos

Last Updated: Dec 28, 2025

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

Published on: March 8, 2012

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering

Published on: January 24, 2025

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Published on: March 1, 2024

Area of Science:

Ophthalmology
Infectious Diseases
Neuro-Ophthalmology

Background:

Syphilis can manifest with optic disc edema (ODE), often attributed to increased intracranial pressure or optic perineuritis.
Previous understanding linked ODE in syphilis to papilledema or optic nerve sheath inflammation.

Purpose of the Study:

To describe a distinct presentation of ocular syphilis characterized by optic disc edema with preserved visual function.
To propose a new term, "incipient syphilitic papillitis," for this specific clinical scenario.

Main Methods:

Retrospective case series of four patients with syphilis presenting with optic disc edema.
Clinical examination, visual function tests, lumbar puncture for intracranial pressure measurement, and magnetic resonance imaging (MRI) of the optic nerves and orbits were performed.

Main Results:

Four patients with syphilis exhibited optic disc edema but maintained normal visual acuity and color vision.
Intracranial pressure was normal in all cases, and MRI revealed no enhancement of the optic nerve or its sheath.
This presentation differs from typical syphilitic optic perineuritis.

Conclusions:

Optic disc edema in syphilis can occur without visual compromise, elevated intracranial pressure, or optic nerve sheath enhancement.
The term "incipient syphilitic papillitis" is proposed for this presentation, suggesting it may be more common than syphilitic optic perineuritis.