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Related Experiment Video

Updated: Dec 28, 2025

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Selective Colour Vision Deficits in Multiple Sclerosis at Different Temporal Stages.

Neda Anssari¹, Reza Vosoughi², Kathy Mullen³

¹Division of Neurology, Department of Medicine, University of Toronto, Toronto, Canada.

Neuro-Ophthalmology (Aeolus Press)

|February 21, 2020

Summary

Multiple sclerosis (MS) can cause color vision deficits. Blue-yellow color vision testing may help differentiate MS stages, aiding understanding of visual pathway involvement.

Keywords:

Multiple sclerosis blue/yellow colour vision psychophysics red/green

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Published on: April 11, 2025

Area of Science:

Ophthalmology
Neuroscience
Visual Science

Background:

Multiple sclerosis (MS) can lead to color vision deficits, even without optic neuritis.
Evidence for selective deficits in the parvocellular-Red/Green (PC-RG) and koniocellular-Blue/Yellow (KC-BY) pathways in MS is inconclusive.

Purpose of the Study:

To investigate selective color vision deficits in individuals with MS at various disease stages.
To determine if specific color vision pathways are affected differently in MS progression.

Main Methods:

Tested 31 MS patients and 20 healthy controls on contrast orientation discrimination thresholds.
Utilized achromatic, red-green, and blue-yellow sinewave gratings at 0.5 and 2 cycles-per-degree (cpd).

Main Results:

Abnormal red-green thresholds at 0.5cpd were observed in established MS.
Abnormal blue-yellow thresholds were found across all MS participants.
These findings suggest differential involvement of color pathways in MS.

Conclusions:

Blue-yellow color vision testing is valuable for differentiating MS chronicity.
Understanding these color vision deficits enhances knowledge of visual pathway mechanisms in MS.