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Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...

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Related Experiment Video

Updated: Dec 28, 2025

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

Encephalomyelitis with Retinopathy in Common Variable Immunodeficiency (CVID).

Samuel E Shribman¹, Jessica Katanga², Nadeem Ali³

¹Department of Neurology, St George's Hospital, London, England.

Neuro-Ophthalmology (Aeolus Press)

|February 21, 2020

Summary

Common variable immunodeficiency (CVID) rarely causes neurological issues. This case highlights encephalomyelitis with retinopathy in a CVID patient due to immunoglobulin non-adherence, featuring extensive diagnostic imaging and biopsies.

Area of Science:

Immunology
Neurology
Ophthalmology

Background:

Keywords:

Encephalomyelitis MRI case report immunodeficiency ophthalmology

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Related Experiment Videos

Last Updated: Dec 28, 2025

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by low immunoglobulin levels.

Neurological complications are rare in CVID, especially since the advent of intravenous immunoglobulin (IVIg) therapy.

Non-adherence to immunoglobulin replacement therapy can lead to recurrent infections and potential systemic complications.