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Tissue Infiltrating Immune Cells as Prognostic Biomarkers in Endometrial Cancer: A Meta-Analysis
Fang Guo1, Yishan Dong1, Qingqing Tan1
1Department of Medical Genetics, Changzhou Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Changzhou 213003, China.
Disease Markers
|February 21, 2020
Summary
High CD8+ and CD45RO+ T cell densities in endometrial cancer (EC) tumors are linked to better patient survival. This meta-analysis clarifies the prognostic role of tumor-infiltrating immune cells in EC.
Area of Science:
- Oncology
- Immunology
- Cancer Research
Background:
- Prognostic significance of tumor-infiltrating immune cells in endometrial cancer (EC) remains controversial.
- Previous studies often had small sample sizes and limited statistical power.
- This meta-analysis aims to clarify the association between immune cells and EC prognosis.
Purpose of the Study:
- To conduct a comprehensive meta-analysis on the relationship between tumor-infiltrating immune cells and EC survival outcomes.
- To consolidate evidence from multiple studies to provide a more robust assessment.
- To investigate specific immune cell types and their prognostic value.
Main Methods:
- Systematic literature search across multiple databases up to December 2019.
- Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) calculated for various survival endpoints (OS, PFS, RFS, DSS, DFS).
- Subgroup analyses performed based on immune cell location, markers, and cancer stage; heterogeneity and publication bias assessed.
Main Results:
- Seventeen studies included; high CD8+ T cell density associated with favorable overall survival (OS), progression-free survival (PFS), disease-specific survival (DSS), and disease-free survival (DFS).
- High CD45RO+ T cell density linked to favorable OS.
- High TAM density associated with worse PFS, but findings for CD8+ T cells and TAMs were not robust in sensitivity analyses.
Conclusions:
- This is the first meta-analysis to investigate tumor-infiltrating immune cells and EC prognosis.
- Elevated CD8+ and CD45RO+ T cell densities within tumors correlate with improved outcomes for EC patients.
- Further research may be needed to confirm the robustness of certain findings.
