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Proteolytic activity, degradation, and dissolution of primary and permanent teeth
Debora Lopes Salles Scheffel1, Jaime Aparecido Cury2, Livia Maria Andaló Tenuta2
1Department of Orthodontics and Pediatric Dentistry, School of Dentistry, São Paulo State University (UNESP), Araraquara, SP, Brazil.
International Journal of Paediatric Dentistry
|February 21, 2020
Summary
Primary and permanent teeth show similar demineralization rates. However, primary teeth exhibit faster collagen degradation, indicating differences in their structural integrity and breakdown processes.
Area of Science:
- Dental Science
- Biomaterials Science
- Biochemistry
Background:
- Tooth composition significantly impacts dissolution and degradation rates.
- Understanding these differences is crucial for pediatric dentistry and restorative treatments.
Purpose of the Study:
- To quantitatively compare the dissolution and degradation characteristics of primary and permanent teeth.
- To investigate the influence of pH on mineral release from enamel and dentin.
Main Methods:
- Incubation of primary and permanent enamel and dentin powders in varying pH buffers.
- Quantification of mineral release (calcium, phosphate) and assessment of matrix metalloproteinase (MMP) activity.
- Evaluation of collagen degradation via dry mass loss, elastic modulus changes, and specific peptide release (ICTP, CTX).
Main Results:
- Similar dissolution rates observed between primary dentin (PrD) and permanent dentin (PeD) after 256 hours.
- Differential mineral release from enamel and dentin at pH 4.5 and 5.5.
- PrD demonstrated significantly higher dry mass loss, reduced elastic modulus, and increased ICTP/CTX release, indicating faster collagen degradation.
Conclusions:
- Demineralization rates are comparable between primary and permanent teeth.
- Collagen degradation occurs more rapidly and extensively in primary teeth compared to permanent teeth.
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